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Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery

Kang Zhang, Yong Huang, Gustavo Pradilla, Betty Tyler, Jin U. Kang
Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD, 21218 USA
Proc. SPIE 7883, 78833Y, 2011

@inproceedings{zhang2011real,

   title={Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery},

   author={Zhang, K. and Huang, Y. and Pradilla, G. and Tyler, B. and Kang, J.U.},

   booktitle={Proc. of SPIE Vol},

   volume={7883},

   pages={78833Y–1},

   year={2011}

}

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This work utilized an ultra-high-speed full-range complex-conjugate-free optical coherence tomography (FD-OCT) system to perform real-time intraoperative imaging to guide two common neurosurgical procedures: the cerebral blood vessel identification and the brain tumor resection. The cerebral blood vessel identification experiment is conducted ex vivo on human cadaver specimen. Specific cerebral arteries and veins in different positions of the specimen are visualized and the spatial relations between adjacent vessels are indentified through real-time 3D visualization. The brain tumor resection experiment is conducted in vivo on 9L gliomas established in rat brains. The normal brain-tumor margin can be clearly identified in depth of the tissue from sagittal, coronal and axial slices of the intraoperatively acquired 3D data set. The real-time full-range FD-OCT guided in vivo rat flank tumor resection is also conducted.
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