Thai V. Hoang, Xavier Cavin, Patrick Schultz, David W. Ritchie
BACKGROUND: Picking images of particles in cryo-electron micrographs is an important step in solving the 3D structures of large macromolecular assemblies. However, in order to achieve sub-nanometre resolution it is often necessary to capture and process many thousands or even several millions of 2D particle images. Thus, a computational bottleneck in reaching high resolution is […]
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Thai V. Hoang, Xavier Cavin, David W. Ritchie
Fitting high resolution protein structures into low resolution cryo-electron microscopy (cryo-EM) density maps is an important technique for modeling the atomic structures of very large macromolecular assemblies. This article presents "gEMfitter", a highly parallel fast Fourier transform (FFT) EM density fitting program which can exploit the special hardware properties of modern graphics processor units (GPUs) […]
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Stefan Lang, Panos Drouvelis, Enkelejda Tafaj, Peter Bastian, Bert Sakmann
Neuron morphology is frequently used to classify cell-types in the mammalian cortex. Apart from the shape of the soma and the axonal projections, morphological classification is largely defined by the dendrites of a neuron and their subcellular compartments, referred to as dendritic spines. The dimensions of a neuron’s dendritic compartment, including its spines, is also […]
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Kannan Umadevi Venkataraju, Mark Kim, Dan Gerszewski, James R. Anderson, Mary Hall
Understanding the neural circuitry of the retina requires us to map the connectivity of individual neurons in large neuronal tissue sections and analyze signal communication across processes from the electron microscopy images. One of the major bottlenecks in the critical path is the image mosaicing process where 2D slices are assembled from scanned microscopy image […]
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Guangming Tan, Ziyu Guo, Mingyu Chen, Dan Meng
Single-particle 3D reconstruction from cryo-electron microscopy (cryo-EM) images is a kernel application of biological molecules analysis, as the computational requirement of which is now beyond PetaFlop for a high-resolution 3D structure. In this paper, we quantitatively analyze the workload, computational intensity and memory performance of the application, parallelize it on an emerging multicore architecture GPU-CUDA. […]
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Won-ki Jeong, Johanna Beyer, Student Member, Markus Hadwiger, Amelio Vazquez, Student Member, Hanspeter Pfister, Senior Member, Ross T. Whitaker
Recent advances in scanning technology provide high resolution EM (Electron Microscopy) datasets that allow neuroscientists to reconstruct complex neural connections in a nervous system. However, due to the enormous size and complexity of the resulting data, segmentation and visualization of neural processes in EM data is usually a difficult and very time-consuming task. In this […]
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Tomoyoshi Shimobaba, Yoshikuni Sato, Junya Miura, Mai Takenouchi, Tomoyoshi Ito
Digital holographic microscopy (DHM) is a well-known powerful method allowing both the amplitude and phase of a specimen to be simultaneously observed. In order to obtain a reconstructed image from a hologram, numerous calculations for the Fresnel diffraction are required. The Fresnel diffraction can be accelerated by the FFT (Fast Fourier Transform) algorithm. However, real-time […]
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D. Castanodiez, H. Mueller, A. Frangakis
The high-throughput needs in electron tomography and in single particle analysis have driven the parallel implementation of several reconstruction algorithms and software packages on computing clusters. Here, we report on the implementation of popular reconstruction algorithms as weighted backprojection, simultaneous iterative reconstruction technique (SIRT) and simultaneous algebraic reconstruction technique (SART) on common graphics processors (GPUs). […]
Xueming Li, Nikolaus Grigorieff, Yifan Cheng
Among all the factors that determine the resolution of a 3D reconstruction by single particle electron cryo-microscopy (cryoEM), the number of particle images used in the dataset plays a major role. More images generally yield better resolution, assuming the imaged protein complex is conformationally and compositionally homogeneous. To facilitate processing of very large datasets, we […]
M. Schmeisser, B. C. Heisen, M. Luettich, B. Busche, F. Hauer, T. Koske, K. H. Knauber, H. Stark
Most known methods for the determination of the structure of macromolecular complexes are limited or at least restricted at some point by their computational demands. Recent developments in information technology such as multicore, parallel and GPU processing can be used to overcome these limitations. In particular, graphics processing units (GPUs), which were originally developed for […]
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