high performance computing on graphics processing units: hgpu.org

The solution of Protein-Ligand Docking Problems can be approached through metaheuristics, and satisfactory metaheuristics can be obtained with hyperheuristics searching in the space of metaheuristics implemented inside a parameterized schema. These hyperheuristics apply several metaheuristics, resulting in high computational costs. To reduce execution times, a shared-memory schema of hyperheuristics is used with four levels of parallelism, two for the hyperheuristic and two for the metaheuristics. The parallel schema is executed in a many-core system in "native mode", and the four-level parallelism allows us to take full advantage of the massive parallelism offered by this architecture and obtain satisfactory fitness and an important reduction of the execution time.