Interventional 4-D Motion Estimation and Reconstruction of Cardiac Vasculature without Motion Periodicity Assumption

C. Rohkohl, G. Lauritsch, L. Biller, M. Prummer, J. Boese, J. Hornegger
Pattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Medical Image Analysis, Volume 14, Issue 5, October 2010, Pages 687-694 (02 June 2010)


   title={Interventional 4-D motion estimation and reconstruction of cardiac vasculature without motion periodicity assumption},

   author={Rohkohl, C. and Lauritsch, G. and Biller, L. and Pr{\”u}mmer, M. and Boese, J. and Hornegger, J.},

   journal={Medical Image Analysis},





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Anatomical and functional information of cardiac vasculature is a key component in the field of interventional cardiology. With the technology of C-arm CT it is possible to reconstruct static intraprocedural 3-D images from angiographic projection data. Current approaches attempt to add the temporal dimension (4-D). In the assumption of periodic heart motion, ECG-gating techniques can be used. However, arrhythmic heart signals and slight breathing motion are degrading image quality frequently. To overcome those problems, we present a reconstruction method based on a 4-D time-continuous B-spline motion field. The temporal component of the motion field is parameterized by the acquisition time and does not assume a periodic heart motion. The analytic dynamic FDK-reconstruction formula is used directly for the motion estimation and image reconstruction. In a physical phantom experiment two vessels of size 3.1 mm and 2.3 mm were reconstructed using the proposed method and an algorithm with periodicity assumption. For a periodic motion both methods obtained an error of 0.1 mm. For a non-periodic motion the proposed method was superior, obtaining an error of 0.3 mm / 0.2 mm in comparison to 1.2 mm / 1.0 mm for the algorithm with periodicty assumption.For a clinical test case of a left coronary artery it could be further shown that the method is capable to produce diameter measurements with an absolute error of 0.1 mm compared to state-of-the-art measurement tools from orthogonal coronary angiography.Further, it is shown for three different clinical cases (left/right coronary artery, coronary sinus) that the proposed method is able to handle a large variability of vascular structures and motion patterns. The complete algorithm is hardware-accelerated using the GPU requiring a computation time of less than 3 minutes for typical clinical scenarios.
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