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Massive exploration of perturbed conditions of the blood coagulation cascade through GPU parallelization

Paolo Cazzaniga, Marco S. Nobile, Daniela Besozzi, Matteo Bellini, Giancarlo Mauri
Universita degli Studi di Bergamo – Dipartimento di Scienze Umane e Sociali, 24129, Bergamo, Italy
BioMed Research International, 2014

@article{cazzanigamassive,

   title={Massive exploration of perturbed conditions of the blood coagulation cascade through GPU parallelization},

   author={Cazzaniga, Paolo and Nobile, Marco S. and Besozzi, Daniela and Bellini, Matteo and Mauri, Giancarlo},

   year={2014}

}

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The introduction of general-purpose Graphics Processing Units (GPUs) is boosting scientific applications in Bioinformatics, Systems Biology and Computational Biology. In these fields, the use of high-performance computing solutions is motivated by the need of performing large numbers of in silico analysis to study the behavior of biological systems in different conditions, which necessitate a computing power that usually overtakes the capability of standard desktop computers. In this work we present coagSODA, a CUDA-powered computational tool that was purposely developed for the analysis of a large mechanistic model of the blood coagulation cascade (BCC), defined according to both mass-action kinetics and Hill functions. coagSODA allows to execute parallel simulations of the dynamics of the BCC by automatically deriving the system of ordinary differential equations, and then exploiting the numerical integration algorithm LSODA. We present the biological results achieved with a massive exploration of perturbed conditions of the BCC, carried out with one-dimensional and bi-dimensional parameter sweep analysis, and show that GPU-accelerated parallel simulations of this model can increase the computational performances up to a 181x speedup compared to the corresponding sequential simulations.
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