Fast free-form deformation using graphics processing units

Marc Modat, Gerard R. Ridgway, Zeike A. Taylor, Manja Lehmann, Josephine Barnes, David J. Hawkes, Nick C. Fox, Sebastien Ourselin
Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, University College London, London, UK
Computer methods and programs in biomedicine, Vol. 98, No. 3. (08 June 2010), pp. 278-284.


   title={Fast free-form deformation using graphics processing units},

   author={Modat, M. and Ridgway, G.R. and Taylor, Z.A. and Lehmann, M. and Barnes, J. and Hawkes, D.J. and Fox, N.C. and Ourselin, S.},

   journal={Computer methods and programs in biomedicine},








A large number of algorithms have been developed to perform non-rigid registration and it is a tool commonly used in medical image analysis. The free-form deformation algorithm is a well-established technique, but is extremely time consuming. In this paper we present a parallel-friendly formulation of the algorithm suitable for graphics processing unit execution. Using our approach we perform registration of T1-weighted MR images in less than 1 min and show the same level of accuracy as a classical serial implementation when performing segmentation propagation. This technology could be of significant utility in time-critical applications such as image-guided interventions, or in the processing of large data sets.
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